Anchoring Change

Integration guide

How to support your brain’s neuroplastic window so what happens in ketamine therapy can grow into lasting, meaningful change.

What is integration?

Integration is everything you do before, between, and after sessions to help your brain’s new ability turn into new ways of thinking, feeling, and living.

Temporary increase in neuroplasticity.

Ketamine temporarily increases neuroplasticity: the brain’s ability to form and strengthen new connections, which peaks over the first 24 hours, meaningfully persists for 2–3 days, and can influence learning and mood for up to two weeks.

Reinforce new habits and ways of thinking.

During that “plastic window,” talk therapy, journaling, movement, sleep, light exposure, relationships, and daily choices all matter more; they’re the input your brain uses to decide which new pathways are worth keeping, and which habits are reinforced. What happens during this integration window largely determines the durability of the benefits.

Schedule ahead.

Schedule a talk-therapy session with your provider to take place 24–48 hours after your ketamine experience—book this appointment before your journey.

Integration Over Time

24 hours

What to keep in mind the day after your journey.

Rest and restore

Give your system time to land.

  • Let your system settle: plan for quiet time after a session.
  • Choose simple, easy-to-digest food.
  • Keep your schedule light and avoid non-essential obligations.
  • Avoid big decisions, arguments, and social media. Your nervous system is open and doesn’t need the extra load.

Note what stood out

Hold onto the thread of the experience.

  • Scribble down key images, phrases, or body sensations as soon as you’re able—short notes are enough.
  • Don’t worry about making sense yet, the goal is to keep the thread so you can return to it with your therapist.

Support sleep and circadian rhythm

Protect the night after your session.

  • Aim for a consistent bedtime.
  • Dim lights in the evening and keep screens to a minimum for at least an hour before sleep.
  • The night after treatment, prioritize 7-9 hours of sleep—this is when emotional memory and learning consolidate.

Be gentle with substances and stimulation

Keep your chemistry and input simple.

  • Avoid alcohol, recreational substances, and extra sedatives in this first window unless medically prescribed.
  • Choose calming activities (music, a bath, a slow walk) over adrenaline-heavy media or doom-scrolling.

First few days

What to keep in mind the week after your journey.

Talk therapy integration

Show up for what came up, with professional support

  • Schedule a talk therapy session ahead of time so that 24–48 hours after ketamine therapy you can unpack the experience—when the plastic window is at its highest
  • Be with whatever comes up, it could be more of a feeling than an epiphany—we don’t always need to analyze or understand, insight can come from sensing as much as figuring out.
  • Integrate whatever you noticed or felt. With your therapist, explore how those shifts might soften old patterns, open up new behaviors, and change how you show up for the people who matter most.

Schedule a talk therapy session for 24-48 hours after,  before you do a journey

Small, meaningful adjustments

Practice the new pathways in real life.

  • Choose one to three small behavior changes that connect to what you're discovering—going to bed 30 minutes earlier, initiating one honest conversation, or taking a short daily walk.
  • Repeat them daily or several times this week so your nervous system gets multiple chances to experience the new pattern.
  • Treat the week as a “practice” not a test. Curiosity and repetition matter more than doing it perfectly.

Movement, breath, being mindful

Help your body feel the change.

  • Use light movement—walking, stretching, yoga—to help stabilize mood and reduce rumination.
  • Add simple breath or mindfulness practices to your day, even for a few minutes at a time.
  • Aim for consistency over intensity: a few minutes most days beats one heroic session.

Light, nature, and screens

Let light and environment work with you, not against you.

  • Get some natural light as soon as you can upon waking. Morning light helps anchor circadian rhythms, energy, and mood.
  • Balance screen time with time outdoors—trees, ocean, sky, or even a small green space all support stress reduction and emotional regulation.

Ongoing


What to keep in mind long term.

Keep working the relational piece

Let relationships be part of the therapeutic process.

  • Use therapy and close relationships as places to practice the shifts you’re aiming for: clearer boundaries, more honesty, more kindness toward yourself and others.
  • Notice where old patterns reappear and treat them as information, not failure.
  • Ask for loved ones to show up. Even if it’s a bit uncomfortable at first, it gets easier and is a great way to co-regulate.

Maintain sleep, light, and rhythm

Build a steady foundation for your body and brain.

  • Prioritize a basic routine: sleep and wake up at roughly the same time each day.
  • Keep doing morning sunlight and an evening wind-down that doesn’t revolve around devices or screens.
  • Remember that these rhythms are some of the most powerful things you can do to keep depression and anxiety from coming back.

Stay connected to body and environment

Keep giving your nervous system anchors.

  • Use ongoing movement, nature contact, gardening, or time in sunlight or water as anchors when mood and motivation wobble.
  • Think of these as maintenance for your nervous system, like sweeping the pathways for your brain and body.

Revisit intentions and adjust

Let your integration evolve with you.

  • Each week, look back at your original intentions—ask yourself what’s shifted and what still needs attention.
  • Remember that integration is ongoing; you and your care team can adapt future sessions, therapy focus, and daily practices based on what you’re discovering.